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GitHub / stefanie-baerthel / combinatorial_treatment_analysis
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and resistant to targeted therapies, immune checkpoint blockade and engineered T cells. In this study, we performed a systematic high throughput combinatorial drug screen and identified a synergistic interaction between the MEK inhibitor trametinib and the multi- kinase inhibitor nintedanib. Using single cell RNA sequencing and immunophenotyping, we show that the combination therapy reprograms the immunosuppressive microenvironment and primes cytotoxic and memory T cells to infiltrate the tumors, thereby sensitizing mesenchymal PDAC to PD-L1 inhibition.
Stars: 1
Forks: 0
Open Issues: 0
License: None
Language: Jupyter Notebook
Repo Size: 70.7 MB
Dependencies: pending
Created: over 2 years ago
Updated: 8 months ago
Last pushed: over 2 years ago
Last synced: 8 months ago
Topics: pancreatic-cancer, scanpy, scrna-seq-analysis, treatment-effects