Open-Systems-Pharmacology/Dextromethorphan-Model

PBPK Model of Dextromethorphan and its Metabolites

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Open-Systems-Pharmacology/Metoprolol-Model

PBPK model of metoprolol and metoprolol-CYP2D6 drug-gene interactions

Size: 91.6 MB - Last synced: 9 days ago - Pushed: over 3 years ago - Stars: 1 - Forks: 1

Open-Systems-Pharmacology/PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling

Language: C# - Size: 256 MB - Last synced: 16 days ago - Pushed: 16 days ago - Stars: 96 - Forks: 48

Open-Systems-Pharmacology/Ritonavir-Model

PBPK model for ritonavir

Language: R - Size: 38.2 MB - Last synced: 24 days ago - Pushed: 24 days ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Quetiapine-Model

Size: 32.7 MB - Last synced: 25 days ago - Pushed: about 3 years ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/Aripiprazole-Model

Size: 95.9 MB - Last synced: 25 days ago - Pushed: about 3 years ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Carbamazepine-Model

PBPK model of carbamazepine as CYP3A4 and CYP2B6 substrate and inducer

Language: MATLAB - Size: 337 KB - Last synced: 3 months ago - Pushed: 3 months ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Carbamazepine-Efavirenz-DDI

Modeling of published clinical Carbamazepine-Efavirenz DDI studies for model evaluation

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Open-Systems-Pharmacology/Cimetidine-Model

Whole-body PBPK model of cimetidine (OCT2/MATE and CYP3A4 DDI perpetrator drug)

Language: MATLAB - Size: 49 MB - Last synced: 3 months ago - Pushed: 3 months ago - Stars: 0 - Forks: 3

Open-Systems-Pharmacology/Carbamazepine-Alprazolam-DDI

Modeling of published clinical Carbamazepine-Alprazolam-DDI studies for model evaluation

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Open-Systems-Pharmacology/Itraconazole-Felodipine-DDI

Size: 17.6 KB - Last synced: 5 months ago - Pushed: 5 months ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Erythromycin-Felodipine-DDI

Size: 13.7 KB - Last synced: 5 months ago - Pushed: 5 months ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Clarithromycin-Sildenafil-DDI

Size: 15.6 KB - Last synced: 5 months ago - Pushed: 5 months ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Atazanavir-Model

Whole-body PBPK model of atazanavir

Language: MATLAB - Size: 84.7 MB - Last synced: 7 months ago - Pushed: about 1 year ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/Trimethoprim-Model

Size: 50.7 MB - Last synced: 7 months ago - Pushed: over 3 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/ISOP-webinar---PK-Sim-MoBi-introduction

ISOP QSP Webinar Series: Bridging and Tackling the Gap between Empirical and Systems Pharmacology Models: Where do we stand? Part 7: PK-Sim/Mobi – Open Systems Pharmacology Suite by Jan Schlender

Size: 10.2 MB - Last synced: 7 months ago - Pushed: almost 7 years ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/Digoxin-Model

Whole-body PBPK model of digoxin as P-gp DDI victim drug

Language: R - Size: 19.7 MB - Last synced: 7 months ago - Pushed: about 1 year ago - Stars: 4 - Forks: 3

Open-Systems-Pharmacology/Pregnancy-Models

Physiologically Based Pharmacokinetic Models for Pregnant Women

Size: 572 MB - Last synced: 7 months ago - Pushed: 9 months ago - Stars: 5 - Forks: 5

Open-Systems-Pharmacology/Tefibazumab-Model

Language: R - Size: 13.7 KB - Last synced: 8 months ago - Pushed: 10 months ago - Stars: 0 - Forks: 3

Open-Systems-Pharmacology/Fentanyl-Model

Physiologically-Based Pharmacokinetic (PBPK) Modeling of Fentanyl in Adults and Pediatric Patients

Size: 84.5 MB - Last synced: 8 months ago - Pushed: over 3 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Amoxicillin-Model Fork of AndreDlm/Amoxicillin-Model

Whole-body PBPK model of intravenously administered amoxicillin for adults, pregnant women and postpartum women

Size: 81.8 MB - Last synced: 8 months ago - Pushed: over 3 years ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Sufentanil-Pediatrics Fork of Incei/Sufentanil-Pediatrics

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Open-Systems-Pharmacology/Raltegravir-Pediatrics Fork of Incei/Raltegravir-Pediatrics

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Open-Systems-Pharmacology/Alfentanil-Pediatrics Fork of Incei/Alfentanil-Pediatrics

Size: 128 KB - Last synced: 8 months ago - Pushed: 10 months ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Voriconazole-Model

Whole-body PBPK model of voriconazole as CYP2C19 substrate and CYP3A4 perpetrator drug

Size: 6.07 MB - Last synced: 5 months ago - Pushed: 10 months ago - Stars: 1 - Forks: 1

Open-Systems-Pharmacology/Ondansetron-Model 📦

Size: 1.95 KB - Last synced: 8 months ago - Pushed: over 4 years ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/Irinotecan-Model 📦

Whole-body PBPK model of Irinotecan (CPT-11) & SN-38 determining tumor tissue kinetics of both parent drug & active metabolite.

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Open-Systems-Pharmacology/7E3-Model

Language: R - Size: 43 KB - Last synced: 8 months ago - Pushed: 10 months ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/BAY794620-Model

Language: R - Size: 16.6 KB - Last synced: 8 months ago - Pushed: 10 months ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/Cabozantinib-Model

Cabozantinib PBPK

Size: 300 KB - Last synced: 8 months ago - Pushed: almost 3 years ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/CDA1-Model

Language: R - Size: 12.7 KB - Last synced: 8 months ago - Pushed: 10 months ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/dAb2-Model

Language: R - Size: 13.7 KB - Last synced: 8 months ago - Pushed: 10 months ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/Exemplary-Protein-Models

Exemplary Protein PBPK Models

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Open-Systems-Pharmacology/Inulin-Model

Language: R - Size: 12.7 KB - Last synced: 8 months ago - Pushed: 10 months ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/Levonorgestrel

Whole-body PBPK model of levonorgestrel with and without ethinyl estradiol as CYP3A4 DDI victim drug

Size: 1.95 KB - Last synced: 8 months ago - Pushed: over 3 years ago - Stars: 1 - Forks: 1

Open-Systems-Pharmacology/MEDI524-Model

Language: R - Size: 12.7 KB - Last synced: 8 months ago - Pushed: 10 months ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/MEDI524YTE-Model

Language: R - Size: 12.7 KB - Last synced: 8 months ago - Pushed: 10 months ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/Tizanidine-Model

Whole-body PBPK model of tizanidine as a substrate of CYP1A2

Language: MATLAB - Size: 42 KB - Last synced: 8 months ago - Pushed: over 1 year ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Quinidine-DDGI-Model

Size: 156 KB - Last synced: 8 months ago - Pushed: 11 months ago - Stars: 1 - Forks: 0

Open-Systems-Pharmacology/Rifampicin-Tacrolimus-DDI

Size: 20.5 KB - Last synced: 8 months ago - Pushed: 11 months ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Voriconazole-Tacrolimus-DDGI

Size: 49.8 KB - Last synced: 8 months ago - Pushed: 11 months ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Itraconazole-Tacrolimus-DDI

Size: 19.5 KB - Last synced: 8 months ago - Pushed: 11 months ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Tacrolimus-Model

Size: 299 KB - Last synced: 8 months ago - Pushed: 11 months ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Quinidine-Model

Size: 53.7 KB - Last synced: 8 months ago - Pushed: 12 months ago - Stars: 1 - Forks: 0

Open-Systems-Pharmacology/Dapagliflozin-Model

Whole-body PBPK model of dapagliflozin

Language: MATLAB - Size: 152 MB - Last synced: 8 months ago - Pushed: about 1 year ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/Ketoconazole-Alprazolam-DDI

Size: 8.65 MB - Last synced: 8 months ago - Pushed: about 1 year ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Ketoconazole-Alfentanil-DDI

Size: 14.8 MB - Last synced: 8 months ago - Pushed: about 1 year ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Omeprazole-Model

Whole-body PBPK model of omeprazole as a substrate of CYP2C19 and CYP3A4 and an inhibitor of CYP2C19.

Language: MATLAB - Size: 102 KB - Last synced: 8 months ago - Pushed: about 1 year ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Moclobemide-Omeprazole-DDI

Modeling of published clinical Moclobemide-Omeprazole-DDI studies for model evaluation

Size: 14.6 KB - Last synced: 8 months ago - Pushed: about 1 year ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Digoxin-Pediatrics

Size: 70.3 KB - Last synced: 8 months ago - Pushed: over 1 year ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/Propofol-Model

Whole-body pbpbk model of Propofol

Language: R - Size: 163 MB - Last synced: 8 months ago - Pushed: about 1 year ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Ketoconazole-Model

Size: 74.6 MB - Last synced: 8 months ago - Pushed: about 1 year ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Ketoconazole-Triazolam-DDI

Size: 6.99 MB - Last synced: 8 months ago - Pushed: about 1 year ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Ketoconazole-Midazolam-DDI

Size: 49.7 MB - Last synced: 8 months ago - Pushed: about 1 year ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Ketoconazole-Digoxin-DDI

Size: 3.53 MB - Last synced: 8 months ago - Pushed: about 1 year ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Warfarin-Model

Size: 28.1 MB - Last synced: 8 months ago - Pushed: over 1 year ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Fluconazole-Model

Whole-body PBPK model of fluconazole

Language: MATLAB - Size: 72.3 KB - Last synced: 8 months ago - Pushed: over 1 year ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/S-Mephenytoin-Model

Whole-body PBPK model of s-mephenytoin as a substrate of CYP2C19

Language: MATLAB - Size: 43.9 KB - Last synced: 8 months ago - Pushed: over 1 year ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Mexiletine-Tizanidine-DDI

Modeling of published clinical Mexiletine-Tizanidine-DDI studies for model evaluation

Size: 12.7 KB - Last synced: 8 months ago - Pushed: over 1 year ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Alfentanil-Model

Whole-body PBPK model of alfentanil as CYP3A4 DDI victim drug

Language: MATLAB - Size: 170 MB - Last synced: 6 months ago - Pushed: over 1 year ago - Stars: 0 - Forks: 3

Open-Systems-Pharmacology/Sildenafil-Model

Language: MATLAB - Size: 74.2 KB - Last synced: 3 months ago - Pushed: 3 months ago - Stars: 0 - Forks: 4

Open-Systems-Pharmacology/Felodipine-Model

Language: MATLAB - Size: 67.4 KB - Last synced: 8 months ago - Pushed: over 1 year ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Midazolam-Model

Whole-body PBPK model of midazolam as CYP3A4 DDI victim drug

Language: MATLAB - Size: 16.7 MB - Last synced: 8 months ago - Pushed: almost 2 years ago - Stars: 0 - Forks: 4

Open-Systems-Pharmacology/Clopidogrel-Model

Whole-body parent-metabolite PBPK model of Clopidogrel for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 DDGI Predictions

Size: 378 KB - Last synced: 8 months ago - Pushed: almost 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Clopidogrel-Bupropion-DDI

Modeling of published clinical Clopidogrel-Bupropion-DDI studies for model evaluation

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Open-Systems-Pharmacology/Clopidogrel-Montelukast-DDI

Modeling of published clinical Clopidogrel-Montelukast-DDI studies for model evaluation

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Open-Systems-Pharmacology/Clopidogrel-Repaglinide-DDI

Modeling of published clinical Clopidogrel-Repaglinide-DDI studies for model evaluation

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Open-Systems-Pharmacology/Omeprazole-Clopidogrel-DDI

Modeling of published clinical Omeprazole-Clopidogrel-DDI studies for model evaluation

Size: 42 KB - Last synced: 8 months ago - Pushed: almost 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Rifampicin-Clopidogrel-DDI

Modeling of published clinical Rifampicin-Clopidogrel-DDI studies for model evaluation

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Open-Systems-Pharmacology/Clopidogrel-Pioglitazone-DDI

Modeling of published clinical Clopidogrel-Pioglitazone-DDI studies for model evaluation

Size: 19.5 KB - Last synced: 8 months ago - Pushed: almost 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Cimetidine-Carbamazepine-DDI

Modeling of published clinical Cimetidine-Carbamazepine DDI studies for model evaluation

Size: 58.6 KB - Last synced: 3 months ago - Pushed: 3 months ago - Stars: 0 - Forks: 3

Open-Systems-Pharmacology/Carbamazepine-Midazolam-DDI

Modeling of published clinical Carbamazepine-Midazolam-DDI studies for model evaluation

Size: 43 KB - Last synced: 4 months ago - Pushed: 4 months ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Erythromycin-Carbamazepine-DDI

Modeling of published clinical Erythromycin-Carbamazepine DDI studies for model evaluation

Size: 54.7 KB - Last synced: 4 months ago - Pushed: 4 months ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Verapamil-Midazolam-DDI

Modeling of published clinical Verapamil-Midazolam-DDI studies for model evaluation

Size: 50.8 KB - Last synced: 8 months ago - Pushed: about 2 years ago - Stars: 0 - Forks: 2

Open-Systems-Pharmacology/Fluvoxamine-Caffeine-DDI

Modeling of published clinical Fluvoxamine-Caffeine-DDI studies for model evaluation

Size: 6.23 MB - Last synced: 8 months ago - Pushed: about 2 years ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Fluvoxamine-Model

Whole-body PBPK model of fluvoxamine as CYP1A2 and CYP3A4 DDI perpetrator drug

Language: MATLAB - Size: 60.2 MB - Last synced: 8 months ago - Pushed: about 2 years ago - Stars: 0 - Forks: 3

Open-Systems-Pharmacology/Erythromycin-Model

Language: MATLAB - Size: 134 KB - Last synced: 8 months ago - Pushed: about 2 years ago - Stars: 0 - Forks: 3

Open-Systems-Pharmacology/Mefenamic-acid-Model

Whole-body PBPK model of mefenamic acid

Language: MATLAB - Size: 464 KB - Last synced: 8 months ago - Pushed: about 2 years ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Mexiletine-Caffeine-DDI

Modeling of published clinical Mexiletine-Caffeine-DDI studies for model evaluation

Size: 12.7 KB - Last synced: 8 months ago - Pushed: about 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Fluvoxamine-Tizanidine-DDI

Modeling of published clinical Fluvoxamine-Tizanidine-DDI studies for model evaluation

Size: 12.7 KB - Last synced: 8 months ago - Pushed: about 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Fluvoxamine-S-mephenytoin-DDI

Modeling of published clinical Fluvoxamine-S-mephenytoin-DDI studies for model evaluation

Size: 14.6 KB - Last synced: 8 months ago - Pushed: about 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Fluvoxamine-Omeprazole-DDI

Modeling of published clinical Fluvoxamine-Omeprazole-DDI studies for model evaluation

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Open-Systems-Pharmacology/Fluvoxamine-Mexiletine-DDI

Modeling of published clinical Fluvoxamine-Mexiletine-DDI studies for model evaluation

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Open-Systems-Pharmacology/Ethinylestradiol-Tizanidine-DDI

Modeling of published clinical Ethinylestradiol-Tizanidine-DDI studies for model evaluation

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Open-Systems-Pharmacology/Ethinylestradiol-Caffeine-DDI

Modeling of published clinical Ethinylestradiol-Caffeine-DDI studies for model evaluation.

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Open-Systems-Pharmacology/Moclobemide-Model

Whole-body PBPK model of moclobemide as a substrate and a moderate inhibitor of CYP2C19

Language: MATLAB - Size: 48.8 KB - Last synced: 8 months ago - Pushed: about 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Mexiletine-Model

Whole-body PBPK model of mexiletine as CYP1A2 DDI substrate and inhibitor drug

Language: MATLAB - Size: 43 KB - Last synced: 8 months ago - Pushed: about 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Ethinylestradiol-Model

Whole-body PBPK model of ethinylestradiol as CYP1A2 DDI perpetrator drug

Language: MATLAB - Size: 53.7 KB - Last synced: 8 months ago - Pushed: about 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Olanzapine-Model

PBPK model of olanzapine

Size: 88.5 MB - Last synced: 8 months ago - Pushed: over 2 years ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Fluconazole-Triazolam-DDI

Modeling of published clinical Fluconazole-Triazolam-DDI studies for model evaluation

Size: 13.7 KB - Last synced: 8 months ago - Pushed: over 2 years ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Fluconazole-Alfentanil-DDI

Modeling of published clinical Fluconazole-Alfentanil-DDI studies for model evaluation

Size: 10.7 KB - Last synced: 8 months ago - Pushed: over 2 years ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Fluconazole-Midazolam-DDI

Modeling of published clinical Fluconazole-Midazolam-DDI studies for model evaluation

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Open-Systems-Pharmacology/Finerenone-Model

Whole-body PBPK model of finerenone (KERENDIA).

Size: 96.7 KB - Last synced: 6 months ago - Pushed: over 2 years ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Rosuvastatin-Model

Whole-body PBPK model of rosuvastatin (OATP1B1/OATP1B3/BCRP DDI victim drug)

Size: 50.5 MB - Last synced: 8 months ago - Pushed: over 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Probenecid-Rosuvastatin-DDI

Modeling of published clinical Probenecid-Rosuvastatin-DDI studies for model evaluation

Size: 3.96 MB - Last synced: 8 months ago - Pushed: over 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Gemfibrozil-Rosuvastatin-DDI

Modeling of published clinical Gemfibrozil-Rosuvastatin-DDI studies for model evaluation

Size: 4.41 MB - Last synced: 8 months ago - Pushed: over 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Rifampicin-Rosuvastatin-DDI

Modeling of published clinical Rifampicin-Rosuvastatin-DDI studies for model evaluation

Size: 15.3 MB - Last synced: 8 months ago - Pushed: over 2 years ago - Stars: 0 - Forks: 0

Open-Systems-Pharmacology/Propofol-Pediatrics

Size: 33.2 KB - Last synced: 8 months ago - Pushed: over 2 years ago - Stars: 0 - Forks: 1

Open-Systems-Pharmacology/Rifampicin-Model

Whole-body PBPK model of rifampicin as CYP3A4 and P-gp DDI perpetrator drug

Language: MATLAB - Size: 19.8 MB - Last synced: 8 months ago - Pushed: over 2 years ago - Stars: 0 - Forks: 4

Open-Systems-Pharmacology/Vancomycin-Model

Whole-body PBPK model of Vancomycin

Language: MATLAB - Size: 75.5 MB - Last synced: 8 months ago - Pushed: over 2 years ago - Stars: 3 - Forks: 2