nbay13/toilkit

A python package for working with inputs to and outputs from the toil-rnaseq pipeline

Language: Python - Size: 802 KB - Last synced: 14 minutes ago - Pushed: about 1 hour ago - Stars: 1 - Forks: 0

opencobra/cobratoolbox

The COnstraint-Based Reconstruction and Analysis Toolbox. Documentation:

Language: MATLAB - Size: 1.02 GB - Last synced: about 5 hours ago - Pushed: about 5 hours ago - Stars: 237 - Forks: 302

scverse/scanpy

Single-cell analysis in Python. Scales to >1M cells.

Language: Python - Size: 38.4 MB - Last synced: about 9 hours ago - Pushed: about 10 hours ago - Stars: 1,761 - Forks: 571

PavlidisLab/gemma.R

An R wrapper for the Gemma RESTful API

Language: R - Size: 79 MB - Last synced: about 11 hours ago - Pushed: about 11 hours ago - Stars: 8 - Forks: 1

GoekeLab/xpore

Identification of differential RNA modifications from nanopore direct RNA sequencing

Language: Python - Size: 4.96 MB - Last synced: about 14 hours ago - Pushed: about 15 hours ago - Stars: 127 - Forks: 22

theislab/scgen

Single cell perturbation prediction

Language: Python - Size: 69 MB - Last synced: 1 day ago - Pushed: 7 months ago - Stars: 247 - Forks: 51

iliapopov17/BI-Workshop-miniProjects

Repository for workshop study projects in Bioinformatics Institute 2023-2024

Language: Jupyter Notebook - Size: 16.1 MB - Last synced: 1 day ago - Pushed: 2 days ago - Stars: 0 - Forks: 0

ablab/IsoQuant

Transcript discovery and quantification with long RNA reads (Nanopores and PacBio)

Language: Python - Size: 18.6 MB - Last synced: about 8 hours ago - Pushed: about 9 hours ago - Stars: 118 - Forks: 11

pinellolab/pyrovelocity

𝒫robabilistic modeling of RNA velocity ⬱

Language: Python - Size: 21.8 MB - Last synced: 3 days ago - Pushed: 3 days ago - Stars: 34 - Forks: 5

microbiomedata/nmdc-schema

National Microbiome Data Collaborative (NMDC) unified data model

Language: Python - Size: 113 MB - Last synced: 1 day ago - Pushed: 1 day ago - Stars: 26 - Forks: 8

2n3m/2n3m

Biomedicine, Pharma, Life Science, IT Consulting

Size: 68.4 KB - Last synced: 3 days ago - Pushed: 3 days ago - Stars: 0 - Forks: 0

nara3m/nara3m

Nara Marella

Size: 30.3 KB - Last synced: 3 days ago - Pushed: 3 days ago - Stars: 0 - Forks: 0

sanjaynagi/rna-seq-pop

Snakemake workflow for Illumina RNA-sequencing experiments - extract population genomic signals from RNA-Seq data

Language: Jupyter Notebook - Size: 99.6 MB - Last synced: 3 days ago - Pushed: 3 days ago - Stars: 17 - Forks: 6

swainasish/SpatialPrompt

spatially aware scalable and accurate tool for spot deconvolution and clustering in spatial transcriptomics

Language: Jupyter Notebook - Size: 12.7 MB - Last synced: 3 days ago - Pushed: 4 days ago - Stars: 6 - Forks: 0

glasgowcompbio/pyMultiOmics

Python toolbox for multi-omics data mapping and analysis

Language: Jupyter Notebook - Size: 45.9 MB - Last synced: 4 days ago - Pushed: about 1 year ago - Stars: 15 - Forks: 4

ncaptier/stabilized-ica

This repository proposes a python implementation of a stabilized ICA algorithm

Language: Python - Size: 61.4 MB - Last synced: 4 days ago - Pushed: 4 days ago - Stars: 18 - Forks: 4

BgeeDB/bgee_pipeline

Source code of the Bgee pipeline used to build the Bgee database

Language: Perl - Size: 1020 MB - Last synced: 4 days ago - Pushed: 4 days ago - Stars: 11 - Forks: 4

yollct/spycone

Spicing-aware time-course network enricher - exploratory analysis for transcriptomics and/or proteomics time series data

Language: Python - Size: 93.9 MB - Last synced: 5 days ago - Pushed: 7 months ago - Stars: 7 - Forks: 0

bpucker/teaching

This repository gives an overview of my teaching activities. Links to slides and data sets are included. Feel free to re-use my content.

Size: 268 MB - Last synced: 4 days ago - Pushed: 5 days ago - Stars: 40 - Forks: 8

nf-core/tfactivity

Bioinformatics pipeline that makes use of expression and open chromatin data to identify differentially active transcription factors across conditions.

Language: Nextflow - Size: 5.07 MB - Last synced: 7 days ago - Pushed: 8 days ago - Stars: 6 - Forks: 0

dalodriguez/ExPCom

Differential communication analysis for scRNAseq datasets based on expression products

Language: R - Size: 41.1 MB - Last synced: 5 days ago - Pushed: 5 days ago - Stars: 0 - Forks: 0

meringlab/annotation_system_assessment

Snakemake pipeline to benchmark 11 functional pathway annotation systems

Language: Python - Size: 7.1 MB - Last synced: 5 days ago - Pushed: almost 2 years ago - Stars: 0 - Forks: 0

keller-mark/awesome-biological-visualizations

A list of web-based interactive biological data visualizations.

Size: 141 KB - Last synced: 1 day ago - Pushed: 27 days ago - Stars: 151 - Forks: 16

tnaake/MatrixQCvis

Language: R - Size: 4.47 MB - Last synced: 17 days ago - Pushed: 17 days ago - Stars: 5 - Forks: 1

cantinilab/HuMMuS

Molecular interactions inference from single-cell multi-omics data

Language: Python - Size: 78.4 MB - Last synced: 6 days ago - Pushed: 6 days ago - Stars: 13 - Forks: 3

JEFworks-Lab/CRAWDAD

Cell-type Relationship Analysis Workflow Done Across Distances

Language: R - Size: 946 MB - Last synced: 6 days ago - Pushed: 7 days ago - Stars: 11 - Forks: 1

pachterlab/voyager

From geospatial to spatial -omics

Language: R - Size: 4.1 GB - Last synced: 8 days ago - Pushed: 9 days ago - Stars: 60 - Forks: 6

babessell1/MADRID Fork of HelikarLab/COMO

Metabolic Drug Repurposing Pipeline

Language: Python - Size: 733 MB - Last synced: 7 days ago - Pushed: 7 days ago - Stars: 4 - Forks: 0

CogDisResLab/drugfindR

Repository holding the code for the drugfindR R package

Language: R - Size: 4.18 MB - Last synced: 7 days ago - Pushed: 7 days ago - Stars: 7 - Forks: 1

scverse/anndata

Annotated data.

Language: Python - Size: 4.33 MB - Last synced: 7 days ago - Pushed: 7 days ago - Stars: 501 - Forks: 150

danilotat/RNA-neoflow

Snakemake workflow to profile MHC-I neoepitopes with bulk tumor RNAseq data

Language: Python - Size: 211 MB - Last synced: 7 days ago - Pushed: 7 days ago - Stars: 1 - Forks: 1

JEFworks-Lab/HoneyBADGER

HMM-integrated Bayesian approach for detecting CNV and LOH events from single-cell RNA-seq data

Language: R - Size: 52.8 MB - Last synced: 3 days ago - Pushed: almost 3 years ago - Stars: 94 - Forks: 31

anergictcell/atg

A Rust library and CLI tool to handle genomic transcripts

Language: Rust - Size: 437 KB - Last synced: 6 days ago - Pushed: 10 days ago - Stars: 4 - Forks: 0

kharchenkolab/pagoda2

R package for analyzing and interactively exploring large-scale single-cell RNA-seq datasets

Language: JavaScript - Size: 78.4 MB - Last synced: about 9 hours ago - Pushed: 2 months ago - Stars: 191 - Forks: 47

zhichaoxu04/MetaR2M

A novel meta-analysis framework of the R-squared (R2)-based mediation effect estimation for high-dimensional omics mediators

Language: R - Size: 1.27 MB - Last synced: 10 days ago - Pushed: 11 days ago - Stars: 1 - Forks: 0

rajewsky-lab/openst

Open-ST: profile and analyze tissue transcriptomes in 3D with high resolution in your lab

Language: HTML - Size: 170 MB - Last synced: 11 days ago - Pushed: 11 days ago - Stars: 25 - Forks: 7

LieberInstitute/Visium_SPG_AD

Visium SPG AD project (n = 10) using Visium Spatial Proteogenomics (Visium-SPG) on dissections from the inferior temporal cortex (ITC) from Alzheimer's disease cases and controls.

Language: HTML - Size: 2.09 GB - Last synced: 9 days ago - Pushed: 10 days ago - Stars: 1 - Forks: 0

owkin/PyDESeq2

A Python implementation of the DESeq2 pipeline for bulk RNA-seq DEA.

Language: Python - Size: 1.29 MB - Last synced: 16 days ago - Pushed: 17 days ago - Stars: 508 - Forks: 55

biomedbigdata/DysRegNet_package

Inferring patient-specific regulatory alterations

Language: Jupyter Notebook - Size: 229 KB - Last synced: 11 days ago - Pushed: 11 days ago - Stars: 2 - Forks: 0

nf-core/spatialvi

Pipeline for processing spatially-resolved gene counts with spatial coordinates and image data. Designed for 10x Genomics Visium transcriptomics.

Language: Nextflow - Size: 6.81 MB - Last synced: 11 days ago - Pushed: 11 days ago - Stars: 39 - Forks: 12

chanzuckerberg/cellxgene

An interactive explorer for single-cell transcriptomics data

Language: JavaScript - Size: 239 MB - Last synced: 11 days ago - Pushed: 11 days ago - Stars: 579 - Forks: 111

lilab-bcb/cirrocumulus

Bring your single-cell data to life

Language: JavaScript - Size: 223 MB - Last synced: 7 days ago - Pushed: 14 days ago - Stars: 63 - Forks: 10

genular/pandora

PANDORA Pan-Dimensional Omics Analysis :computer:

Language: Vue - Size: 15.7 MB - Last synced: 16 days ago - Pushed: 17 days ago - Stars: 131 - Forks: 20

sanjaynagi/AnoExpress

Anopheles gene expression in insecticide resistance studies

Language: Jupyter Notebook - Size: 82.1 MB - Last synced: 2 days ago - Pushed: 4 months ago - Stars: 2 - Forks: 0

saezlab/liver-disease-atlas

Transcriptomic cross-species analysis of chronic liver disease reveals consistent regulation between humans and mice

Language: R - Size: 71.9 MB - Last synced: 14 days ago - Pushed: over 2 years ago - Stars: 1 - Forks: 3

saezlab/hepatic-microenviroment

Gut microbiota fuels HCC development by shaping the hepatic inflammatory microenvironment

Language: R - Size: 188 KB - Last synced: 14 days ago - Pushed: almost 4 years ago - Stars: 1 - Forks: 0

saezlab/HIF1A-activity-salmonella

Conditional deletion of HIF-1a provides new insight regarding the murine response to gastrointestinal infection with Salmonella Typhimurium

Language: R - Size: 2.79 MB - Last synced: 14 days ago - Pushed: about 3 years ago - Stars: 0 - Forks: 1

saezlab/cosmosR

COSMOS (Causal Oriented Search of Multi-Omic Space) is a method that integrates phosphoproteomics, transcriptomics, and metabolomics data sets.

Language: R - Size: 45.1 MB - Last synced: 14 days ago - Pushed: 4 months ago - Stars: 52 - Forks: 15

obophenotype/cell-ontology

An ontology of cell types

Language: Makefile - Size: 316 MB - Last synced: 17 days ago - Pushed: 17 days ago - Stars: 130 - Forks: 47

soedinglab/transannot

TransAnnot - a fast transcriptome annotation pipeline

Language: C - Size: 72.5 MB - Last synced: 14 days ago - Pushed: 15 days ago - Stars: 2 - Forks: 1

GoekeLab/sg-nex-data

Nanopore RNA-Seq data from the Singapore Nanopore-Expression Project

Language: Jupyter Notebook - Size: 2.36 MB - Last synced: about 2 months ago - Pushed: about 2 months ago - Stars: 87 - Forks: 23

ZJUFanLab/scDeepSort

Cell-type Annotation for Single-cell Transcriptomics using Deep Learning with a Weighted Graph Neural Network

Language: Python - Size: 19.4 MB - Last synced: 7 days ago - Pushed: 10 months ago - Stars: 93 - Forks: 17

PiotrTymoszuk/htGLMNET

High Throughput Light Weight Regularized Regression Modeling for Molecular Data

Language: R - Size: 43.4 MB - Last synced: 17 days ago - Pushed: 17 days ago - Stars: 0 - Forks: 0

sdomanskyi/DigitalCellSorter

Digital Cell Sorter (DCS): single cell RNA-seq analysis toolkit. Documentation:

Language: Python - Size: 1020 MB - Last synced: 10 days ago - Pushed: almost 3 years ago - Stars: 22 - Forks: 10

COMBINE-lab/alevin-fry

🐟 🔬🦀 alevin-fry is an efficient and flexible tool for processing single-cell sequencing data, currently focused on single-cell transcriptomics and feature barcoding.

Language: Rust - Size: 4.08 MB - Last synced: 15 days ago - Pushed: about 2 months ago - Stars: 149 - Forks: 15

GuyTeichman/RNAlysis

RNA sequencing analysis software

Language: Python - Size: 609 MB - Last synced: 5 days ago - Pushed: 5 days ago - Stars: 119 - Forks: 13

stemangiola/tidybulk

Brings bulk and pseudobulk transcriptomics to the tidyverse

Language: R - Size: 95 MB - Last synced: about 14 hours ago - Pushed: about 15 hours ago - Stars: 159 - Forks: 23

saezlab/decoupler-py

Python package to perform enrichment analysis from omics data.

Language: Python - Size: 68.9 MB - Last synced: 14 days ago - Pushed: about 1 month ago - Stars: 130 - Forks: 19

popitsch/rnalib

rnalib: a python-based transcriptomics library

Language: Jupyter Notebook - Size: 319 MB - Last synced: 19 days ago - Pushed: 19 days ago - Stars: 1 - Forks: 0

nanoporetech/pychopper 📦

A tool to identify, orient, trim and rescue full length cDNA reads

Language: Python - Size: 52 MB - Last synced: 6 days ago - Pushed: almost 2 years ago - Stars: 77 - Forks: 22

mariachiaragrieco/bulk-RNAseq

bulk-RNAseq analysis for Transcriptomics Course 2021 (MSc Bioinformatics for Computational Genomics)

Language: HTML - Size: 5.96 MB - Last synced: 20 days ago - Pushed: about 2 years ago - Stars: 0 - Forks: 0

mariachiaragrieco/sc-RNAseq-colon

sc-RNAseq analysis for Transcriptomics Course 2021 (MSc Bioinformatics for Computational Genomics)

Size: 18.8 MB - Last synced: 20 days ago - Pushed: about 2 years ago - Stars: 0 - Forks: 0

NathanSkene/EWCE

Expression Weighted Celltype Enrichment. See the package website for up-to-date instructions on usage.

Language: R - Size: 35.4 MB - Last synced: 20 days ago - Pushed: 21 days ago - Stars: 52 - Forks: 24

AliSajid/QTExpTool

What the Package Does (Title Case)

Language: R - Size: 570 KB - Last synced: 21 days ago - Pushed: over 1 year ago - Stars: 0 - Forks: 0

dohlee/chromoformer

The official code implementation for Chromoformer in PyTorch. (Lee et al., Nature Communications. 2022)

Language: Python - Size: 137 MB - Last synced: 13 days ago - Pushed: 9 months ago - Stars: 29 - Forks: 0

jr-leary7/scLANE

Characterize gene dynamics over trajectories using GLMs, GEEs, & GLMMs.

Language: R - Size: 28.1 MB - Last synced: 22 days ago - Pushed: 22 days ago - Stars: 7 - Forks: 2

benben-miao/TOmicsVis

Transcriptomics Visualization R package.

Language: R - Size: 198 MB - Last synced: 19 days ago - Pushed: 4 months ago - Stars: 56 - Forks: 11

spacetx/starfish

starfish: unified pipelines for image-based transcriptomics

Language: Python - Size: 114 MB - Last synced: 5 days ago - Pushed: about 1 month ago - Stars: 220 - Forks: 66

iSEE/iSEE

R/shiny interface for interactive visualization of data in SummarizedExperiment objects

Language: R - Size: 16.3 MB - Last synced: 24 days ago - Pushed: 25 days ago - Stars: 217 - Forks: 41

LieberInstitute/deconvo_lute-paper

Contains analysis for the lute software paper

Language: HTML - Size: 541 MB - Last synced: 25 days ago - Pushed: 25 days ago - Stars: 0 - Forks: 0

cran-task-views/Omics

CRAN Task View: Genomics, Proteomics, Metabolomics, Transcriptomics, and Other Omics

Size: 72.3 KB - Last synced: 25 days ago - Pushed: 25 days ago - Stars: 15 - Forks: 4

becavin-lab/bacnet

BACNET is a Java based platform to develop website for multi-omics analysis

Language: Java - Size: 148 MB - Last synced: 10 days ago - Pushed: about 1 year ago - Stars: 13 - Forks: 1

aertslab/pySCENIC

pySCENIC is a lightning-fast python implementation of the SCENIC pipeline (Single-Cell rEgulatory Network Inference and Clustering) which enables biologists to infer transcription factors, gene regulatory networks and cell types from single-cell RNA-seq data.

Language: Python - Size: 34.7 MB - Last synced: 21 days ago - Pushed: 21 days ago - Stars: 371 - Forks: 175

ELTEbioinformatics/mulea Fork of koralgooll/MulEA

mulea - an R package for enrichment analysis using various ontologies and empirical FDR correction

Language: R - Size: 296 MB - Last synced: 26 days ago - Pushed: 27 days ago - Stars: 8 - Forks: 1

raw-lab/metaome_stats

Statistical package for metaome denovo assembly results.

Language: Python - Size: 2.64 MB - Last synced: 26 days ago - Pushed: over 1 year ago - Stars: 2 - Forks: 16

Novartis/cellxgene-gateway

Cellxgene Gateway allows you to use the Cellxgene Server provided by the Chan Zuckerberg Institute (https://github.com/chanzuckerberg/cellxgene) with multiple datasets.

Language: Python - Size: 203 KB - Last synced: 13 days ago - Pushed: about 2 months ago - Stars: 52 - Forks: 32

hms-dbmi/scde

R package for analyzing single-cell RNA-seq data

Language: R - Size: 14 MB - Last synced: 13 days ago - Pushed: 2 months ago - Stars: 170 - Forks: 68

moritzmadern/BulkRNAseqAnalysis_from_countMatrix

R Markdown script to perform standard analysis steps for bulk RNA-seq count matrices. Analysis steps include: Adding biomaRt annotation, filtering and QC, normalization, general visualization (PCA, heatmaps), k-means clustering + ORA, differential expression testing via DESeq2 + GSEA, and finally export of results as text file and html report.

Language: R - Size: 29 MB - Last synced: 29 days ago - Pushed: about 1 month ago - Stars: 2 - Forks: 0

urmi-21/MetaOmGraph

MetaOmGraph: a workbench for interactive exploratory data analysis of large expression datasets

Language: Java - Size: 175 MB - Last synced: 29 days ago - Pushed: almost 2 years ago - Stars: 32 - Forks: 14

DeplanckeLab/ASAP

ASAP : Automated Single-cell Analysis Pipeline

Language: Java - Size: 170 MB - Last synced: 26 days ago - Pushed: 26 days ago - Stars: 23 - Forks: 10

thelovelab/fishpond

Differential expression and allelic analysis, nonparametric statistics

Language: R - Size: 7.01 MB - Last synced: 20 days ago - Pushed: 8 months ago - Stars: 24 - Forks: 9

C4TB/shinyExprPortal

Deploy interactive Shiny portals for exploration and showcase of analysis of molecular expression and phenotype data using a configuration file.

Language: R - Size: 7.64 MB - Last synced: 16 days ago - Pushed: 3 months ago - Stars: 4 - Forks: 1

MartinLoza/Canek

Unbiased integration of single cell transcriptomes.

Language: R - Size: 38.4 MB - Last synced: 14 days ago - Pushed: 4 months ago - Stars: 4 - Forks: 1

sablokgaurav/trinity-blast-machine-learning

a scalable and faster implementation for the genome and the transcriptome annotations for large scale sequencing datasets.

Language: Python - Size: 45.9 KB - Last synced: about 1 month ago - Pushed: about 1 month ago - Stars: 0 - Forks: 0

sablokgaurav/genomic-alignment-extraction

A scalable large scale genomic fraction aligner and extractor for the large scale alignment of the genomes and the transcriptomes and process them over the cores for the extraction of the aligned regions. The aligned regions can also be mapped to the length plotter and can be machine trained for specific applications

Language: Python - Size: 71.3 KB - Last synced: about 1 month ago - Pushed: about 1 month ago - Stars: 1 - Forks: 0

theislab/diffxpy

Differential expression analysis for single-cell RNA-seq data.

Language: Python - Size: 1.71 MB - Last synced: 25 days ago - Pushed: 11 months ago - Stars: 171 - Forks: 23

LieberInstitute/spatialDLPFC

spatialDLPFC project involving Visium (n = 30), Visium SPG (n = 4) and snRNA-seq (n = 19) samples

Language: HTML - Size: 14.9 GB - Last synced: 10 days ago - Pushed: 10 days ago - Stars: 10 - Forks: 0

almeidasilvaf/HybridExpress_paper

Data and code associated with the paper "HybridExpress: an R/Bioconductor package for comparative transcriptomic analyses of hybrids and their progenitors"

Language: JavaScript - Size: 11.4 MB - Last synced: about 1 month ago - Pushed: about 1 month ago - Stars: 1 - Forks: 0

ZJUFanLab/scCATCH

Automatic Annotation on Cell Types of Clusters from Single-Cell RNA Sequencing Data

Language: R - Size: 52 MB - Last synced: 30 days ago - Pushed: 12 months ago - Stars: 201 - Forks: 36

MatthiasLienhard/isotools

IsoTools is a python module for Long Read Transcriptome Sequencing (LRTS) analysis.

Language: Jupyter Notebook - Size: 38 MB - Last synced: 20 days ago - Pushed: 7 months ago - Stars: 19 - Forks: 5

AllenInstitute/scrattch.hicat

Hierarchical, iterative clustering for analysis of transcriptomics data in R

Language: HTML - Size: 154 MB - Last synced: about 1 month ago - Pushed: about 1 month ago - Stars: 95 - Forks: 31

VerisimilitudeX/DNAnalyzer

Revolutionizing DNA analysis and making it accessible to all through innovative AI-powered analysis and interpretive tools

Language: Java - Size: 188 MB - Last synced: about 1 month ago - Pushed: about 1 month ago - Stars: 125 - Forks: 55

pietrocinaglia/fape

Flexible Automated Pipeline Engine (FAPE)

Size: 7.93 MB - Last synced: about 1 month ago - Pushed: about 1 month ago - Stars: 0 - Forks: 0

colbyford/zebrafish_mecp2_expression

Behavioral and Transcriptomic Analyses of mecp2 Function in Zebrafish

Language: HTML - Size: 120 MB - Last synced: about 1 month ago - Pushed: about 1 month ago - Stars: 3 - Forks: 0

OceanGenomics/mudskipper

A tool for projecting genomic alignments to transcriptomic coordinates

Language: Rust - Size: 18.3 MB - Last synced: 26 days ago - Pushed: 8 months ago - Stars: 28 - Forks: 7

jackbibby1/SCPA

R package for pathway analysis in scRNA-seq data

Language: R - Size: 41.6 MB - Last synced: about 1 month ago - Pushed: about 1 month ago - Stars: 43 - Forks: 4

Neal-Liu1/Multi-omics-integration

Contains code related to my multi-omics integration project at WEHI.

Language: R - Size: 136 KB - Last synced: about 1 month ago - Pushed: about 1 month ago - Stars: 1 - Forks: 0

gogleva/ShinyTranscriptomes

project for Cambridge Bioinformatics Hackathon, 25-27 Sept 2017

Language: R - Size: 895 KB - Last synced: about 1 month ago - Pushed: over 6 years ago - Stars: 1 - Forks: 0

gogleva/PublicPalmivora

Reproducible scripts for (P. Carella et al) manuscript

Language: R - Size: 1.67 MB - Last synced: about 1 month ago - Pushed: over 6 years ago - Stars: 0 - Forks: 0

pallavisurana1/TransTEx

R package for TransTEx: Novel tissue-specificity scoring method for grouping human transcriptome in-to different expression groups

Language: R - Size: 18.6 KB - Last synced: about 1 month ago - Pushed: about 1 month ago - Stars: 0 - Forks: 1